Efficient Synthesis of 2-Substituted Imidazoles by Palladium-Catalyzed Cross-Coupling with Benzylzinc Reagents

Abstract

Substituted benzylzinc reagents have been used in novel cross-coupling reactions with 2-iodo imidazoles to form compounds containing both a phenol and an imidazole moiety. The ­intramolecular hydrogen-bonding properties of these compounds were subsequently studied.

Key words

cross-coupling - palladium - zinc - benzylation - heterocycles

References and Notes

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4

The calculations will be reported separately together with further analyses of the target compounds.

13

This reagent is also commercially available from Aldrich.

16

Compound 9c was not deprotected due to lack of material.