Synthesis of New Dehydro 2-Azatryptophans and Derivatives via Heck Cross-Coupling Reactions of 3-Iodoindazoles with Methyl 2-(Acetylamino)acrylate

François Crestey; Valérie Collot; Silvia Stiebing; Sylvain Rault

doi:10.1055/s-2006-950242

PAPER

Synthesis of New Dehydro 2-Azatryptophans and Derivatives via Heck Cross-Coupling Reactions of 3-Iodoindazoles with Methyl 2-(Acetylamino)acrylate

François Crestey, Valérie Collot*, Silvia Stiebing, Sylvain Rault
Centre d’Etudes et de Recherche sur le Médicament de Normandie (CERMN), UPRES EA-3915, U.F.R. des Sciences Pharmaceutiques, Université de Caen Basse-Normandie, 5 rue Vaubénard, 14032 Caen Cedex, France
Fax: +33(2)31931188; e-Mail: valerie.collot@unicaen.fr;

Abstract

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Abstract

This paper describes the Heck cross-coupling reaction of 3-iodoindazoles with methyl 2-(acetylamino)acrylate as a general route to new dehydro 2-azatryptophans and protected amino acid derivatives after catalytic hydrogenation.

Key words

dehydro 2-azatryptophans - protective amino acid derivatives - catalytic hydrogenation - Heck cross-coupling reaction - 3-iodoindazoles - 2-(acetylamino)acrylate

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Referenzen

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