Pharmacopsychiatry 2007; 40(1): 37-38
DOI: 10.1055/s-2006-951609
Letter

© Georg Thieme Verlag KG Stuttgart · New York

A Case of Aripiprazole-induced Mania

R. Traber 1 , R. Schneiter 1 , J. Modestin 1
  • 1University of Zurich, Department of Psychiatry, Burghölzli Hospital, Zurich, Switzerland
Further Information

Publication History

received 21. 6. 2006 revised 8. 8. 2006

accepted 11. 8. 2006

Publication Date:
27 February 2007 (online)

Introduction

Aripiprazole is a novel atypical neuroleptic. It acts as a partial agonist at the dopamine D2 receptor, as a partial agonist at the 5-HT1A receptor, and as an antagonist at the 5-HT2A receptor. Clinical trials have established its clinical efficacy and favorable tolerability profile [5] [16]. Nevertheless, infrequent undesirable adverse events are often encountered during wide-scale everyday clinical use. Induction of mania, described for almost all second-generation neuroleptics [2] [3] [11] [15] [17], may be one of the rare adverse events of aripiprazole therapy.

We present a case of an induction of mania after initiation of aripiprazole treatment in a male patient with chronic schizophrenia who had never presented affective symptoms and had been without continuous medication for several years.

References

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Correspondence

J. Modestin

University of Zurich·Department of Psychiatry

Burghölzli Hospital

Lenggstrasse 31

CH-8029 Zurich

Switzerland

Phone: +41/44/384 26 70

Fax: +41/44/384 27 19

Email: modestin@bli.unizh.ch