Planta Med 2007; 73(1): 77-83
DOI: 10.1055/s-2006-951766
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Phytochemical Investigation of Perovskia abrotanoides

Simin Khaliq1 , 2 , Franz-Josef Volk1 , August Wilhelm Frahm1
  • 1Department of Pharmaceutical Chemistry, University of Freiburg, Freiburg, Germany
  • 2Ph. D. thesis (University of Freiburg) of SK constitutes a fraction of this investigation
Further Information

Publication History

Received: April 26, 2006

Accepted: October 8, 2006

Publication Date:
18 December 2006 (online)

Abstract

The phytochemical investigation of the n-hexane, the EtOAc, and the n-BuOH soluble fractions of the methanolic extract of the arial parts of Perovskia abrotanoides Karelin furnished ten compounds including the two new tetracyclic diterpenes abrotandiol (7) and abrotanone (8) besides the known cirsimaritin (9), hespiridin (10), rosmarinic acid (11), stigmast-5-en-3β-ol (12), stigmast-5,22-dien-3β-ol (13), stigmast-5-en-3β,7α-diol (14), ursolic acid (15) and betulinic acid (16). Compounds 7 and 8 both show a 6,5,6,6 ring skeleton with a trans-1,1-dimethylcyclohexano[e,b]tetrahydrofuran element perpendicular to a benzodihydropyran system. The complete structure elucidation of these compounds has been achieved with NMR techniques.

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Prof. Dr. August Wilhelm Frahm

Department of Pharmaceutical Chemistry

Institut für Pharmazeutische Wissenschaften

University of Freiburg

Albertstr. 25

79104 Freiburg

Germany

Phone: +49-761-203-6334

Fax: +49-761-203-6351

Email: August.Wilhelm.Frahm@pharmazie.uni-freiburg.de