Neurobiologie alkoholbedingten Suchtverhaltens

Deutsche Hauptstelle für Suchtfragen. Jahrbuch Sucht 2006.. Geeshacht: Neuland 2006
Hemström Ö, Leifman H, Ramstedt M. The ECAS survey on drinking patterns and alcohol-related problems in European Comparative Alcohol Study.. Swedish National Institute of Health 2004

Genetische Zusammenhänge

Grant BF. The impact of a family history of alcoholism on the relationship between age at onset of alcohol use and DSM-IV alcohol dependence - Results from the National Longitudinal Alcohol Epidemiologic Survey.. Alcohol Health & Research World 1998; 22: 144-147
Heinz A, Jones DW, Mazzanti C. et al. A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity.. Biol Psychiatry 2000; 47: 643-649
Oroszi G, Goldman D. Alcoholism: genes and mechanisms.. Pharmacogenomics 2004; 5: 1037-1048
Schuckit MA, Mazzanti C, Smith TL. et al. Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABA alpha 6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study.. Biol Psychiatry 1999; 45: 647-651
Schuckit MA, Smith TL. An 8-year follow-up of 450 sons of alcoholic and control subjects.. Arch Gen Psychiatry 1996; 53: 202-210

Neurotransmitter

Heinz A, Jones DW, Gorey JG. et al. Serotonin transporter availability correlates with alcohol intake in non-human primates.. Mol Psychiatry 2003; 8: 231-234
Koob GF. Moal M Le . Drug abuse: hedonic homeostatic dysregulation.. Science 1997; 278: 52-58
Krystal JH, Petrakis IL, Limoncelli D. et al. Altered NMDA glutamate receptor antagonist response in recovering ethanol-dependent patients.. Neuropsychopharmacology 2003; 28: 2020-2028
Spanagel R, Pendyala G, Abarca C. et al. The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption.. NatMed 2005; 11: 35-42

Langfristige neurobiologische Auswirkungen

Chiara G Di . The role of dopamine in drug abuse viewed from the perspective of its role in motivation.. Drug Alcohol Depend 1995; 38: 95-137
George MS, Anton RF, Bloomer C. et al. Activation of prefrontal cortex and anterior thalamus in alcoholic subjects on exposure to alcohol-specific cues.. Arch Gen Psychiatry 2001; 58: 345-352
Heinz A, Siessmeier T, Wrase J. et al. Correlation between dopamine D(2) receptors in the ventral striatum and central processing of alcohol cues and craving.. Am J Psychiatry 2004; 161: 1783-1789
Schultz W, Dayan P, Montague PR. A neural substrate of prediction and reward.. Science 1997; 275: 1593-1599

Die Rolle neuroendokriner Peptide

Fahlke C, Eriksson CJP. Effect of adrenalectomy and exposure to corticosterone on alcohol intake in alcohol-preferring and alcohol-avoiding rat lines.. Alcohol and Alcoholism 2000; 35: 139-144
Heinz A, Rommelspacher H, Graf KJ, Kurten I, Otto M, Baumgartner A. Hypothalamic-Pituitary-Gonadal Axis, Prolactin, and Cortisol in Alcoholics During Withdrawal and After 3 Weeks of Abstinence - Comparison with Healthy Control Subjects.. Psychiatry Research 1995; 56: 81-95
Kiefer F, Jahn H, Kellner M, Naber D, Wiedemann K. Leptin as a possible modulator of craving for alcohol.. Arch Gen Psychiatry 2001; 58: 509-510
Kiefer F, Jahn H, Schick M, Wiedemann K. Alcohol self-administration, craving and HPA-axis activity: an intriguing relationship.. Psychopharmacology 2002; 164: 239-240
Kiefer F, Wiedemann K. Neuroendocrine pathways of addictive behaviour.. Addict Biol 2004; 9: 205-212
O'Brien CP, Childress AR, Ehrman R, Robbins SJ. Conditioning factors in drug abuse: can they explain compulsion?. J Psychopharmacol 1998; 12: 15-22
Sillaber I, Rammes G, Zimmermann S. et al. Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors.. Science 2002; 296: 931-933

Therapeutische Konsequenzen

Heinz A, Lober S, Georgi A. et al. Reward craving and withdrawal relief craving: assessment of different motivational pathways to alcohol intake.. Alcohol Alcohol 2003; 38: 35-39
Heinz A, Reimold M, Wrase J. et al. Correlation of stable elevations in striatal mu-opioid receptor availability in detoxified alcoholic patients with alcohol craving: a positron emission tomography study using carbon 11-labeled carfentanil.. Arch Gen Psychiatry 2005; 62: 57-64
Kiefer F, Jahn H, Tarnaske T. et al. Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism.. Arch Gen Psychiatry 2003; 60: 92-99
Mann K. Pharmacotherapy of alcohol dependence: a review of the clinical data.. CNS Drugs 2004; 18: 485-504
Mann K, Diehl A, Hein J, Heinz A. Alkoholabhängigkeit in Therapie psychischer Erkrankungen - State of the art.. München, Jena: Urban & Fischer 2006
Wiesbeck GA, Weijers HG, Lesch OM, Glaser T, Toennes PJ, Boening J. Flupenthixol decanoate and relapse prevention in alcoholics: results from a placebo-controlled study.. Alcohol Alcohol 2001; 36: 329-334