Zusammenfassung
Zonisamid besitzt in vieler Hinsicht ein günstiges pharmakokinetisches Profil. Das Antikonvulsivum wird rasch resorbiert, hat eine hohe, von der Nahrungsaufnahme unabhängige Bioverfügbarkeit und kann aufgrund der langen Halbwertszeit von etwa 60 Stunden ohne Gefahr nächtlicher Anfälle ein- oder auch zweimal täglich eingenommen werden. Mit anderen, häufig eingesetzten Antikonvulsiva wie Carbamazepin, Phenytoin, Valproat und Lamotrigin führt Zonisamid zu keinen klinisch relevanten Interaktionen, wenngleich Antikonvulsiva, die auf Cyp3A4-Isoenzyme induzierend wirken, den Metabolismus von Zonisamid beeinflussen können.
Abstract
From many points of view zonisamide possesses a favourable pharmacokinetic profile. The anticonvulsive agent is rapidly absorbed, has a high bioavailability independent of the consumption of food and can, on account of its long half-life of about 60 hours, be taken once or also twice a day without the danger of night-time seizures. Zonisamide does not have any clinically relevant interactions with other frequently administered anticonvulsive agents such as carbamazepine, phenytoin, valproate and lamotrigine. However, anticonvulsants that induce the Cyp3A4 isoenzyme may influence the metabolism of zonisamide.
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Prof. Dr. Hermann Stefan
Epilepsiezentrum Erlangen, Neurologische Universitätsklinik
Schwabachanlage 6
91054 Erlangen
eMail: hermann.stefan@neuro.imed.uni-erlangen.de
