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Horm Metab Res 2006; 38(11): 761-766
DOI: 10.1055/s-2006-955089
Original Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Arabinoxylan Fibre Consumption Improved Glucose Metabolism, but did not Affect Serum Adipokines in Subjects with Impaired Glucose Tolerance

A. L. Garcia 1 , J. Steiniger 1 , S. C. Reich 1 , M. O. Weickert 2 , I. Harsch 3 , A. Machowetz 1 , M. Mohlig 2 , J. Spranger 2 , N. N. Rudovich 2 , F. Meuser 4 , J. Doerfer 4 , N. Katz 5 , M. Speth 5 , H. J. F. Zunft 1 , 6 , A. H. F. Pfeiffer 2 , C. Koebnick 1 , 7
  • 1Dietary Fibre and the Metabolic Syndrome Group, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany
  • 2Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
  • 3Medical Department I, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany
  • 4Institute of Food Technology and Food Chemistry, Technical University Berlin, Berlin, Germany
  • 5Department of Clinical Chemistry, University of Giessen, Giessen, Germany
  • 6Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
  • 7Department of Preventive Medicine, University of Southern California, USA
Further Information

Publication History

Received 16 February 2006

Accepted after second revision 13 June 2006

Publication Date:
16 November 2006 (online)

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Abstract

The consumption of arabinoxylan, a soluble fibre fraction, has been shown to improve glycemic control in type 2 diabetic subjects. Soluble dietary fibre may modulate gastrointestinal or adipose tissue hormones regulating food intake. The present study investigated the effects of arabinoxylan consumption on serum glucose, insulin, lipids, leptin, adiponectin and resistin in subjects with impaired glucose tolerance. In a randomized, single-blind, controlled, crossover intervention trial, 11 adults consumed white bread rolls as either placebo or supplemented with 15 g arabinoxylan for 6 weeks with a 6-week washout period. Fasting serum glucose, insulin, triglycerides, unesterified fatty acids, apolipoprotein A1 and B, adiponectin, resistin and leptin were assessed before and after intervention. Fasting serum glucose, serum triglycerides and apolipoprotein A-1 were significantly lower during arabinoxylan consumption compared to placebo (p=0.029, p=0.047; p=0.029, respectively). No effects of arabinoxylan were observed for insulin, adiponectin, leptin and resistin as well as for apolipoprotein B, and unesterified fatty acids. In conclusion, the consumption of AX in subjects with impaired glucose tolerance improved fasting serum glucose, and triglycerides. However, this beneficial effect was not accompanied by changes in fasting adipokine concentrations.

Key words

Dietary fibre - arabinoxylan - adiponectin - resistin - leptin

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Correspondence

Corinna KoebnickPh.D. 

Department of Preventive Medicine·University of Southern California

2250 Alcazar St

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USA

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Email: koebnick@usc.edu.de