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Horm Metab Res 2006; 38(11): 767-772
DOI: 10.1055/s-2006-955090
Original Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Increased Prolactin in Acute Coronary Syndromes as Putative Co-activator of ADP-stimulated P-Selectin Expression

D. Raaz 1 , H. Wallaschofski 2 , C. Stumpf 1 , A. Yilmaz 1 , I. Cicha 1 , L. Klinghammer 1 , W. G. Daniel 1 , T. Lohmann 3 , C. D. Garlichs 1
  • 1Medical Clinic 2, University Hospital Erlangen, Germany
  • 2Medical Clinic A, University Clinic of Greifswald, Germany
  • 3City Hospital Dresden-Neustadt, Germany
Further Information

Publication History

Received 23 February 2006

Accepted after revision 28 August 2006

Publication Date:
16 November 2006 (online)

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Abstract

Prolactin and leptin are newly recognized platelet co-stimulators due to enhancement of ADP-induced platelet aggregation. The aim of our study was to assess whether both hormones prolactin and leptin play a role as co-activators of platelet activation in patients with acute coronary syndromes. Twenty-one patients with acute coronary syndromes, 10 with stable angina pectoris and 10 controls were studied. Patients with acute coronary syndromes showed significantly higher prolactin and leptin values and a significant increased P-selectin expression on platelets compared to patients with stable angina pectoris or controls. However, patients with acute myocardial infarction as a subgroup of acute coronary syndromes showed the highest prolactin levels as well as ADP stimulated P-selectin expression. In the myocardial infarction subgroup prolactin values showed a significant correlation to ADP stimulated P-selectin expression on platelets (r2=0.41; p=0.025), whereas leptin was not correlated. Our data indicate an association between increased prolactin values and enhanced P-selectin expression on platelets in patients with acute coronary syndromes. Therefore, the stress hormone prolactin could be a co-stimulator of platelet activation in these patients. In contrast, the putative platelet activator leptin does not seem to play a major role in acute coronary syndromes.

Key words

Coronary artery disease - acute myocardial infarction - platelets - leptin - angina pectoris - hormones

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1 DR and HW have contributed equally to this work.

Correspondence

Dr. Dorette Raaz

Department of Cardiology·Medical Clinic 2·University Hospital Erlangen

Ulmenweg 18

91054 Erlangen

Germany

Phone: +49/9131/85 35 30 1

Fax: +49/9131/85 35 30 3

Email: dorette.raaz@med2.imed.uni-erlangen.de