Abstract
Synovial sarcoma of the mediastinum is a rare neoplasm that has overlapping histological and immunophenotypic features with other tumors in the differential diagnosis. We describe a case of this disease. The tumor was located at the right side of the pericardium, where an FDG‐PET scan showed an uptake. It was resected, a resection which was complicated by the necessity of partially resecting the pericaridium and right middle lobe which were invaded by the tumor. The doubling time of the main tumor [1] was 11.8 days. The margin of the resected specimen was tumor-free both macro- and microscopically. Reverse transcription-PCR confirmed the diagnosis of synovial sarcoma. The patient rejected chemotherapy or radiation therapy, and had recurrent tumors only one month after the operation. Finally, she opted to have only palliative care and died 79 days after the operation.
Key words
Thoracic surgery - synovial sarcoma - mediastinal tumor
References
-
1
Schwartz M.
A biomathematical approach to clinical tumor growth.
Cancer.
1961;
14
1272-1294
-
2 Enzinger F M, Weiss S W. Soft Tissue Tumors. 3rd ed. St. Louis; Mosby 1995
-
3
dos Santos N R, de Bruijn D R, van Kessel A G.
Molecular mechanisms underlying human synovial sarcoma development.
Genes Chromosomes Cancer.
2001;
30
1-14
-
4
Yano M, Toyooka S, Tsukuda K, Dote H, Morimoto Y, Ohata N. et al .
SYT‐SSX fusion genes in synovial sarcoma of the thorax.
Lung Cancer.
2004;
44
391-397
-
5
Okamoto S, Hisaoka M, Daa T, Hatakeyama K, Iwamasa T, Hashimoto H.
Primary pulmonary synovial sarcoma: a clinicopathologic, immunohistochemical, and molecular study of 11 cases.
Hum Pathol.
2004;
35
850-856
-
6
Ladanyi M.
Fusions of the SYT and SSX genes in synovial sarcoma.
Oncogene.
2001;
20
5755-5762
-
7
Trassard M, Le Doussal V, Hacene K, Terrier P, Ranchere D, Guillou L. et al .
Prognostic factors in localized primary synovial sarcoma: a multicenter study of 128 adults patients.
J Clin Oncol.
2001;
19
525-534
-
8
Oda Y, Hashimoto H, Tsuneyoshi M, Takeshita S.
Survival in synovial sarcoma: a multivariate study of prognostic factors with special emphasis on the comparison between early death and long-term survival.
Am J Surg Pathol.
1993;
17
33-44
MD Hiromichi Katakura
Department of Thoracic Surgery
Kyoto University
Sakyo-ku, Shogoin Kawahara-cho 54
Kyoto 606-8507
Japan
Phone: + 81 7 57 51 49 75
Fax: + 81 7 57 51 49 74
Email: katakura@otsu.jrc.or.jp
