Nosokomiale Pneumonie: aktuelle Therapie

Schlüsselwörter

Pneumonie - Therapie - antimikrobielle Substanzen - Prognose

Key words

pneumonia - treatment - antimicrobial agents - outcome

Literatur

• 1 Torres A, Ewig S. Diagnosing ventilator-associated pneumonia.  N Engl J Med. 2004;  350 433-435
• 2 Kollef F MH, Kollef F KE. et al . Antibiotic utilization and outcomes for patients with clinically suspected ventilator-associated pneumonia and negative quantitative BAL culture results.  Chest. 2005;  128 2706-2713
• 3 Singh N, Rogers P, Atwood C W, Wagener M M, Yu V L. Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. A proposed solution for indiscriminate antibiotic prescription.  Am J Respir Crit Care Med. 2000;  162 505-511
• 4 Niederman M S, Hoeffken G. Nosocomial pneumonia: the importance of a de-escalating strategy for antibiotic treatment of pneumonia in the ICU.  Chest. 2002;  122 2183-2196
• 5 Hilf M, Yu V L, Sharp J. et al . Antibiotic therapy for Pseudomonas aeruginosa bacteremia: outcome correlations in a prospective study of 200 patients.  Am J Med. 1989;  87 540-546
• 6 Bliziotis I A, Samonis G, Vardakas K Z, Chrysanthopoulou S, Falag M E. Effect of aminoglycoside and β-lactam combination therapy versus b-lactam monotherapy on the emergence of antimicrobial resistance: A meta-analysis of randomized, controlled Trials.  Clin Infect Dis. 2005;  41 149-158
• 7 Paul M, Benuri-Silbiger I, Soares-Weiser K, Leibovici L. Beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy for sepsis in immunocompetent patients: systematic review and meta-analysis of randomised trials.  BMJ. 2004;  328 668-672
• 8 Paul M, Silbiger I, Grozinsky S, Soares-Weiser K, Leibovici L. Beta lactam antibiotic monotherapy versus beta lactam-aminoglycoside antibiotic combination therapy for sepsis.  Cochrane Database Syst Rev. 2005;  CD003344
• 9 Safdar N, Handelsman J, Maki D G. Does combination antimicrobial therapy reduce mortality in Gram-negative bacteraemia? A meta-analysis.  Lancet Infect Dis. 2004;  4 519-527
• 10 American Thoracic Society, Infectious Diseases Society of America . Guidelines for the management of adults with hospital-acquired, ventilator-associated and healthcare-associated pneumonia.  Am J Respir Crit Care Med. 2005;  171 388-416
• 11 Chamot E, Boffi E l, Amari E, Rohner P, Van Delden C. Effectiveness of combination antimicrobial therapy for Pseudomonas aeruginosa bacteremia.  Antimicrob Agents Chemother. 2003;  47 2756-2764
• 12 Micek S T, Lloyd A E, Ritchie D J. et al . Pseudomonas aeruginosa bloodstream infection: importance of appropriate initial antimicrobial treatment.  Antimicrob Agents Chemother. 2005;  49 1306-1311
• 13 Chastre J, Wolff M, Fagon J Y. et al . Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial.  JAMA. 2003;  290 2588-2598
• 14 Hamer D H. Treatment of nosocomial pneumonia and tracheobronchitis caused by multidrug-resistant Pseudomonas aeruginosa with aerosolized colistin.  Am J Respir Crit Care Med. 2000;  162 328-330
• 15 Dennesen P J, van der Ven A J, Kessels A G, Ramsay G, Bonten M J. Resolution of infectious parameters after antimicrobial therapy in patients with ventilator-associated pneumonia.  Am J Respir Crit Care Med. 2001;  163 1371-1375
• 16 Ioanas M, Ewig S, Torres A. Treatment failures in patients with ventilator-associated pneumonia.  Infect Dis Clin North Am. 2003;  17 753-771
• 17 Ioanas M, Ferrer M, Cavalcanti M. et al . Causes and predictors of nonresponse to treatment of intensive care unit-acquired pneumonia.  Crit Care Med. 2004;  32 938-945
• 18 Pereira Gomes J C, Pedreira W L. et al . Impact of BAL in the management of pneumonia with treatment failure: positivity of BAL culture under antibiotic therapy.  Chest. 2000;  118 1739-1746
• 19 Wu C L, Yang D, Wang N Y, Kuo H T, Chen P Z. Quantitative culture of endotracheal aspirates in the diagnosis of ventilator-associated pneumonia in patients with treatment failure.  Chest. 2002;  122 662-668