Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis

Jeffrey C. Horowitz; Victor J. Thannickal

doi:10.1055/s-2006-957332

Seminars in Respiratory and Critical Care Medicine, Inhaltsverzeichnis

Semin Respir Crit Care Med 2006; 27(6): 600-612
DOI: 10.1055/s-2006-957332

Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis

Jeffrey C. Horowitz¹ , Victor J. Thannickal¹

¹Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan

Abstract

ABSTRACT

Pulmonary fibrosis represents the sequelae of a variety of acute and chronic lung injuries of known and unknown etiologies. Tissue specimens obtained from patients with pulmonary fibrosis, regardless of the etiology, consistently show evidence of an ongoing wound-repair response. Epithelial-mesenchymal interactions have critical roles in normal lung development, tissue repair processes, and fibrosis. Current hypotheses propose that dysregulated function of, and impaired communication between, epithelial and mesenchymal cells prevent resolution of the wound-repair response and contribute to the pathobiology of pulmonary fibrosis. This hypothesis is supported by abundant evidence from patients, animal models, and cell-culture studies demonstrating abnormalities in epithelial cell and mesenchymal cell activities including proliferation, differentiation, and survival. This article reviews the aberrant epithelial and mesenchymal cellular phenotypes found in the context of pulmonary fibrosis and discusses the mechanisms that perpetuate these cellular phenotypes.

KEYWORDS

Fibroblast - myofibroblast - apoptosis - wound repair - extracellular matrix

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Referenzen

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Jeffrey C HorowitzM.D.

Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center

6301 MSRB III, 1150 W. Medical Center Dr., Ann Arbor, MI 48109

eMail: jchorow@umich.edu