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Horm Metab Res 2007; 39(1): 53-55
DOI: 10.1055/s-2006-957346
Original Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Positive Correlation of Galanin with Glucose in Healthy Volunteers during an Oral Glucose Tolerance Test

I. N. Legakis 1 , T. Mantzouridis 2 , T. Mountokalakis 3
  • 1Henry Dynant Hospital, Department of Endocrinology, Athens, Greece
  • 2Laboratory of Medical Biopathology, Medical School, Evgenidion Hospital, University of Athens, Athens, Greece
  • 3Sotiria Hospital, Department of Internal Medicine, University of Athens, Athens, Greece
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Publikationsverlauf

Received 12. 6. 2006

Accepted 16. 10. 2006

Publikationsdatum:
16. Januar 2007 (online)

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Abstract

Galanin has been found in increased amounts in subjects with type 2 diabetes. The purpose of the present study was to determine the levels of galanin in healthy volunteers during an oral glucose tolerance test (OGTT). We enrolled 11 healthy volunteers, 4 males aged 48±3.56 years with BMI 27±0.5 kg/m2 and 7 females aged 41.3±3.05 years with BMI 27.6±0.9 kg/m2. All were in good health without cardiac, hepatic, renal or other chronic disease. None were taking any medication affecting glucose tolerance (β-blockers, thiazide diuretics, and corticoids) and none had a first degree relative with type 2 diabetes. Glucose tolerance was determined by using the International Expert Committee criteria. Blood samples were collected at 0, 30, 60, 90, 120 and 180 minutes for the measurement of plasma glucose, insulin, C-peptide and human galanin (hGal). During the OGTT, hGal exhibited a significant increase from time 0 to 90 minutes (p < 0.001) and returned to the basal values at 180 minutes, while a positive correlation of blood glucose with hGal was observed during the time scale of OGTT. A significant increase was detected both in insulin and C-peptide from the early beginning of the test at 30 minutes, which remained steady until 90 minutes, and returned gradually to the basal values at 180 minutes. No relationship was found either between hGal and serum insulin, or between hGal and serum C-peptide among the healthy subjects, during the OGTT.

Key words

tolerance - insulin - C-peptide - fasting state - homeostasis

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Correspondence

I. N. Legakis

Department of Endocrinology

“Henry Dunant” Hospital

27, Navarinou Street

155 62 Athens

Greece

Telefon: +3021065 26 655

Fax: +3021060 02 975

eMail: ilegak@med.uoa.gr