Trypanocidal Effects of Gallic Acid and Related Compounds

Tatsuo Koide; Mitsuhiko Nose; Makoto Inoue; Yukio Ogihara; Yoshisada Yabu; Nobuo Ohta

doi:10.1055/s-2006-957360

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Planta Med 1998; 64(1): 27-30
DOI: 10.1055/s-2006-957360

Papers

Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Trypanocidal Effects of Gallic Acid and Related Compounds

Tatsuo Koide¹ , Mitsuhiko Nose^, , Makoto Inoue¹ , Yukio Ogihara¹ , Yoshisada Yabu² , Nobuo Ohta²

¹Department of Pharmacognosy and Plant Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
²Department of Medical Zoology, Nagoya City University Medical School, Nagoya, Japan

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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

Gallic acid (3,4,5-trihydroxybenzoic acid) is a naturally abundant plant phenolic compound and it is well known as a component of hydrolyzable tannins. We report here that gallic acid and related compounds have trypanocidal activity against Trypanosoma brucei brucei (GUTat 3.1) in both the long slender bloodstream forms and the procyclic forms, in vitro. LD₅₀ values of gallic acid are 46.96 ± 1.28 µM for bloodstream forms and 30.02 ± 3.49 for procyclic forms, respectively. A study of structurally related compounds suggested that the pyrogallol moiety could be responsible for this activity.

Key words

Gallic acid - Trypanosoma brucei brucei - trypanocidal activity - bloodstream forms - procyclic forms