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Planta Med 1998; 64(1): 70-72
DOI: 10.1055/s-2006-957370
Letters

© Georg Thieme Verlag Stuttgart · New York

Antimalarial Xanthones from Garcinia cowa

Kittisak Likhitwitayawuid1 , Thatree Phadungcharoen1 , Jerapan Krungkrai2
  • 1Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
  • 2Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

Five xanthones from the bark of Garcinia cowa, namely 7-O-methylgarcinone E (1), cowanin (2), cowanol (3), cowaxanthone (4), and β-mangostin (5), were found to possess in vitro antimalarial activity against Plasmodium falciparum with IC50 values ranging from 1.50 to 3.00 µg/ml. Complete 1H- and 13C-NMR assignments of these compounds are also reported.