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Planta Med 1998; 64(1): 73-74
DOI: 10.1055/s-2006-957371
Letters

© Georg Thieme Verlag Stuttgart · New York

Pinusolidic Acid: A Platelet-Activating Factor Inhibitor from Biota orientalis

Hyun Ok Yang1 , 2 , Byung Hoon Han1
  • 1Natural Products Research Institute, Seoul National Universiy, Seoul, Korea
  • 2Present Address: Asan Institute for Life Sciences, Dept. of Traditional Medicine, Seoul, Korea
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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

The water extract of Biota orientalis showed a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets using [3 H]PAF as a ligand in our previous screening studies for Korean medicinal antagonists by the activitiy-guided purification studies. Another active compound, compound 1 (IC50 = 2.3 × 10-5M, 7.48 ± 2.11 µg/ml, n = 4) was isolated from the title plant. The chemical structure of compound 1 was elucidated as pinusolidic acid by chemical and spectrometric analyses