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Planta Med 1998; 64(1): 91-93
DOI: 10.1055/s-2006-957381
Letters

© Georg Thieme Verlag Stuttgart · New York

Cytotoxic and Antimalarial Alkaloids from Brunsvigia littoralis

William E. Campbell1 , Jerald J. Nair1 , David W. Gammon1 , Jaume Bastida2 , Carles Codina2 , Francesc Viladomat2 , Peter J. Smith3 , Carl F. Albrecht4
  • 1Department of Chemistry, University of Cape Town, Rondebosch, South Africa
  • 2Department de Productes Naturals, Universitat de Barcelona, Barcelona, Spain
  • 3Department of Pharmacology, University of Cape Town, Observatory, South Africa
  • 4Department of Pharmacology, University of Stellenbosch, Tygerberg, South Africa
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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

Four known alkaloids, lycorine (1), 1,2-di-O-acetylly-corine (2), ambeiline (3), and crinine (4) were isolated from the bulbs of Brunsvigia littoralis (Amaryllidaceae). 1H- and 13C-NMR spectra of 2 were completely assigned by means of ID- and 2D-NMR techniques. The alkaloids (1-4) together with the synthesised 11-O-acetylambelline (3a) and 3-O-acetylcrinine (4a) were tested for antimalarial activity with two strains of cultured Plasmodium falciparum and for cytotoxicity with BL6 mouse melanoma cells. Structures 1 and 2 exhibited both antimalarial and cytotoxic activity.