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DOI: 10.1055/s-2006-957390
© Georg Thieme Verlag Stuttgart · New York
A Comparative Study of the Analgesic and Anti-Inflammatory Activities of Pectolinarin Isolated from Cirsium subcoriaceum and Linarin Isolated from Buddleia cordata
Publication History
1997
1997
Publication Date:
04 January 2007 (online)
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Abstract
The dried aqueous extract of aerial parts of Cirsium subcoriaceum (Asteraceae) and its major flavonoid glycoside, pectolinarin, have been evaluated for analgesic and anti-inflammatory effects in mice and rats, respectively. Both the extract and pectolinarin exerted significant and dose-dependent analgesic and anti-inflammatory activities. Also, the anti-inflammatory activities of an aqueous extract of Buddleia cordata and its principal glycoside linarin were evaluated. The results of pharmacological testing proved that linarin is a better anti-inflammatory agent than pectolinarin and indomethacin. On the other hand, pectolinarin exerted a better analgesic effect than linarin.
Key words
Cirsium subcoriaceum - Buddleia cordata - flavone - pectolinarin - linarin - analgesic - anti-inflammatory