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Planta Med 1998; 64(2): 192-193
DOI: 10.1055/s-2006-957405
Letters
Letter
© Georg Thieme Verlag Stuttgart · New York

Alkamides from Phyllanthus fraternus

A. A. Sittie1 , 3 , E. Lemmich1 , C. E. Olsen3 , L. Hviid4 , S. Brøgger Christensen1
  • 1Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Copenhagen Ø, Denmark
  • 2Centre for Scientific Research into Plant Medicine, Mampong-Akwapim, Ghana
  • 3Chemistry Department, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
  • 4Centre for Medical Parasitology, Copenhagen University Hospital (Rigshospitalet), Copenhagen N, Denmark
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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have been isolated from Phyllanthus fraternus, a plant used in Ghanaian traditional medicine to treat malaria. The compounds possess an α,β,γ,δ-unsaturated conjugated amide, a feature believed to enhance antiplasmodial activity. By means of an in vitro assay the two alkamides have been shown to possess moderate antiplasmodial activity.