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Planta Med 1998; 64(4): 332-334
DOI: 10.1055/s-2006-957445
Papers
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Torilin, a Sesquiterpene from Torilis japonica, Reverses Multidrug-Resistance in Cancer Cells

Se Eun Kim1 , Young Ho Kim1 , 3 , Young Choong Kim2 , Jung Joon Lee1
  • 1Natural Product Biosynthesis RU., Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea
  • 2College of Pharmacy, Seoul National University, Seoul, Korea
  • 3College of Pharmacy, Chungnam National University, Taejon, Korea
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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

A sesquiterpene compound reversing multidrug-resistance in cancer cells was isolated from the fruits of Torilis japonica and the structure was identified as torilin. Torilin potentiated the cytotoxicities of adriamycin, vinblastine, taxol and colchicine against multidrug-resistant KB-V1 and MCF7/ADR cells.

Key words

Torilis japonica - Umbelliferae - torilin - sesquiterpene - multidrug-resistance (MDR)