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Planta Med 1998; 64(4): 335-338
DOI: 10.1055/s-2006-957446
Papers
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Mode of Action of Torilin in Multidrug-Resistant Cancer Cell Lines

Se Eun Kim1 , Young Soo Hong1 , Young Choong Kim2 , Juang Joon Lee1
  • 1Natural Product Biosynthesis RU., Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea
  • 2College of Pharmacy, Seoul National University, Seoul, Korea
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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

The mechanism of action of multidrug-resistance reversing activity of torilin was studied. In vitro experiments for the accumulation and efflux of vinblastine clearly indicated that MDR reversing effects of torilin would directly be associated with the increase of the intracellular accumulation of anticancer drugs by blocking the drug efflux. Furthermore, torilin increased the membrane ATPase activity from KB-V1 cells, suggesting that torilin might function by inhibiting drug transport mediated by P-glycoprotein

Key words

Torilin - Torilis japonica - Umbelliferae - multidrug-resistance (MDR) - drug accumulation and efflux - membrane ATPase - drug transport