Planta Medica, Table of Contents Planta Med 1998; 64(4): 362-366DOI: 10.1055/s-2006-957452 Papers Natural Product Chemistry © Georg Thieme Verlag Stuttgart · New York Two Epimeric Pairs of C-4-Acetyl Annonaceous Acetogenins from Goniothalamus donnaiensis Zhong Jiang, Ruo-Yun Chen, Ying Chen, De-Quan Yu Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China Recommend Article Abstract PDF Download Buy Article Abstract Further studies on the roots of Goniothalamus donnaiensis Finet et Gagnap (Annonaceae) led to the isolation of two pairs of Annonaceous acetogenins, donnaienin C (1) and 34-epi-donnaienin C (1′), donnaienin D (2) and 34-epi-donnaienin D (2′), containing a rare γ-hydroxymethyl-γ-lactone moiety and a C-4-acetoxy group. Their structures were elucidated by spectral data and chemical derivatization. Preliminary pharmacological tests showed that the mixture of donnaienin C(1) and 34-epi-donnaienin C (1′) inhibited human hepatoma (Bel) cell lines in vitro (IC50, 7.1 µg/ml). Key words Goniothalamus donnaiensis - Annonaceae - C-4-acetyl Annonaceous acetogenins - donnaienin C - 34-epi-donnaienin C - donnaienin D - 34-epi-donnaienin D PDF (299 kb)
