Planta Med 1998; 64(4): 370-372
DOI: 10.1055/s-2006-957454
Letters

© Georg Thieme Verlag Stuttgart · New York

Lupeol is the Cytotoxic Principle in the Leaf Extract of Dendropanax cf. querceti

Debra M. Moriarty1 , Jin Huang2 , Cherie A. Yancey1 , Ping Zhang1 , William N. Setzer2 , Robert O. Lawton1 , Robert B. Bates3 , Sriyani Caldera3
  • 1Department of Biological Sciences, The University of Alabama in Huntsville, Huntsville, U.S.A.
  • 2Department of Chemistry, The University of Alabama in Huntsville, Huntsville, U.S.A.
  • 3Department of Chemistry, The University of Arizona, Tucson, U.S.A.
Further Information

Publication History

1997

1997

Publication Date:
04 January 2007 (online)

Abstract

The crude ethanol extract from the leaves of Dendropanax cf. querceti (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-G2, A-431, and H-4IIE tumor cell lines. The active component has been isolated by activity-directed separation and identified by 1H- and 13C-NMR spectroscopy as the triterpene lupeol. The mechanism of cytotoxic activity of lupeol has been determined to be inhibition of topoisomerase II.