Planta Med 1998; 64(5): 393-396
DOI: 10.1055/s-2006-957466
Papers
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Antioxidant and Lipophilic Constituents of Tinospora crispa

Alexandre Cavin1 , Kurt Hostettmann1 , Wahjo Dyatmyko2 , Olivier Potterat1
  • 1Institut de Pharmacognosie et Phytochimie, Université de Lausanne, Lausanne, Switzerland
  • 2Fakultas Pascasarjana, Universitas Airlangga, Surabaya, Indonesia
Further Information

Publication History

1997

1997

Publication Date:
04 January 2007 (online)

Abstract

TLC autographic assays revealed in the CH2Cl2 extract of Tinospora crispa Miers (Menispermaceae) the presence of three compounds exhibiting antioxidant and radical scavenging properties towards β-carotene and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. They were isolated and identified as N-cis-feruloyltyramine (4), (N-trans-feruloyltyramine (6) and secoisolariciresinol (5). When tested in dilution assays on the reduction of the DPPH radical, these 3 compounds proved to be more active than the synthetic antioxidant butylhydroxytoluene (BHT). Further investigation of the CH2Cl2 extract led to the isolation of vanillin, syringin, the alkaloid N-formylnornuciferin and the diterpene derivatives borapetosides B and C. In addition, a LC/UV/MS analysis enabled the on-line identification of borapetoside F and N-formylannonain.