Reynosin from Sassurea lappa as Inhibitor on CINC-1 Induction in LPS-Stimulated NRK-52E Cells

Jee H. Jung; Joo Young Ha; Kyung Rak Min; Futoshi Shibata; Hideo Nakagawa; Sam Sik Kang; Il-Moo Chang; Youngsoo Kim

doi:10.1055/s-2006-957480

Planta Med 1998; 64(5): 454-455
DOI: 10.1055/s-2006-957480

Letters

Reynosin from Sassurea lappa as Inhibitor on CINC-1 Induction in LPS-Stimulated NRK-52E Cells

Jee H. Jung¹ , Joo Young Ha² , Kyung Rak Min² , Futoshi Shibata³ , Hideo Nakagawa³ , Sam Sik Kang⁴ , Il-Moo Chang⁴ , Youngsoo Kim²

¹College of Pharmacy, Pusan National University, Pusan, Korea
²College of Pharmacy, Chungbuk National University, Cheongju, Korea
³Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
⁴Natural Products Research Institute, Seoul National University, Seoul, Korea

Abstract

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Abstract

An inhibitor on CINC-1 (cytokine-induced neutrophil chemoattractant-1) induction in LPS-stimulated rat kidney epithelioid NRK-52E cells was purified from the roots of Sassurea lappa Clarke, a herbal medicine used in Korean traditional prescriptions for gastric intestinal diseases by a variety of column chromatographic procedures. The inhibitor was identified as reynosin, a sesquiterpene lactone isolated and characterized previously from Ambrosia confertiflora DC, and Magnolia grand-iflora L. Reynosin exhibited a dose-dependent inhibition on CINC-1 induction in LPS-stimulated NRK-52E cells, where 50% of inhibitory effect was shown at the concentration of about 1 µM.

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