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DOI: 10.1055/s-2006-957484
© Georg Thieme Verlag Stuttgart · New York
Cytotoxic 2,3-Secoaromadendrane-Type Sesquiterpenoids from the Liverwort Plagiochila ovalifolia
Publication History
1997
1998
Publication Date:
04 January 2007 (online)

Abstract
The ether extract of the Japanese liverwort, Plagiochila ovalifolia Mitt. (Plagiochilaceae) yielded three 2,3-secoaro-madendrane-type sesquiterpenoids, plagiochiline-A-15-yl octanoate, 14-hydroxyplagiochiline-A-15-yl 2E,4E-dodecadienoate and 14-hydroxyplagiochiline-A-15-yl 2E,4E,8Z-tetradecatrienoate. The two latter compounds were first isolated from the Plagiochila species. The structures of the new compounds were elucidated by spectroscopy. Plagiochiline-A-15-yl octanoate and 14-hydroxyplagiochiline-A-15-yl 2E,4E-dodecadienoate showed significant cytotoxicity against P-388 murine leukemia tumor cells, both compounds exhibiting an ID50 of 0.05 µg/ml. Plagiochiline A also showed cytotoxic activity. The ID50 was 3.0 µg/ml.