Licochalcone A: An Inducer of Cell Differentiation and Cytotoxic Agent from Pogostemon cabling1

Eun Jung Park; Hae Ran Park; Ji Suk Lee; Jinwoong Kim

doi:10.1055/s-2006-957485

Planta Medica, Table of Contents

Planta Med 1998; 64(5): 464-466
DOI: 10.1055/s-2006-957485

Letters

Licochalcone A: An Inducer of Cell Differentiation and Cytotoxic Agent from Pogostemon cabling ¹

Eun Jung Park² , Hae Ran Park² , Ji Suk Lee² , Jinwoong Kim²

²College of Pharmacy, Seoul National University, Seoul, Republic of Korea

1 Part 2 in the series “Screening and isolation of the cell differentiation inducers from medicinal plants”. For part 1, See ref.(1)

Abstract

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Abstract

Licochalcone A (1), ombuin (2), and 5,7-dihydroxy-3′,4′-dimethoxyflavanone (3) were isolated from the aerial parts of Pogostemon cablin by cytotoxicity-guided fractionation. Compound 1 showed in vitro cytotoxicity and PI-PLCγ1 inhibition activity. Treatment of promyelocytic leukemia cells (HL-60) with compound 1 induced terminal differentiation with the generation of monocyte using nonspecific acid esterase assay.

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Licochalcone A: An Inducer of Cell Differentiation and Cytotoxic Agent from Pogostemon cabling 1

Licochalcone A: An Inducer of Cell Differentiation and Cytotoxic Agent from Pogostemon cabling ¹