Download PDF
Planta Med 1998; 64(5): 482-483
DOI: 10.1055/s-2006-957493
Letters

© Georg Thieme Verlag Stuttgart · New York

Supercritical Carbon Dioxide Extraction of Podophyllotoxin from Dysosma pleiantha Roots

Young Hae Choi1 , Jung Yeon Kim1 , Jung Hwan Ryu2 , Ki-Pung Yoo2 , Yuan Shiun Chang3 , Jinwoong Kim1
  • 1College of Pharmacy, Seoul National University, Seoul, Republic of Korea
  • 2Department of Chemical Engineering, Sogang University, Seoul, Republic of Korea
  • 3China Medical College, Taichung, Republic of China
Further Information

Publication History

1997

1998

Publication Date:
04 January 2007 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

Supercritical fluid extraction (SFE) was utilized to extract podophyllotoxin from the roots of Dysosma pleiantha. The extraction was carried out in the temperature range of 40-80 °C and the pressure range of 13.6-34.0 MPa with supercritical carbon dioxide. However, podophyllotoxin was not sufficiently extracted by pure supercritical carbon dioxide. Methanol was used as modifier to enhance the extraction yield of podophyllotoxin. As a result, SFE produced a higher recovery of podophyllotoxin than conventional 95% ethanol extraction.