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Planta Med 1998; 64(6): 516-519
DOI: 10.1055/s-2006-957505
Papers
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Prenylflavonoids: A New Class of Non-Steroidal Phytoestrogen (Part 2). Estrogenic Effects of 18-Isopentenylnaringenin on Bone Metabolism

Masaaki Miyamoto1 , Yoichi Matsushita1 , Akiko Kiyokawa1 , Chie Fukuda1 , Yasuteru lijima1 , Machiko Sugano2 , Toshiyuki Akiyama2
  • 1Pharmacology and Molecular Biology Research Laboratories, Sankyo Co., Tokyo, Japan
  • 2Exploratory Chemistry Research Laboratories, Sankyo Co., Tokyo, Japan
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Publication History

1997

1998

Publication Date:
01 February 2007 (online)

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Abstract

In order to examine whether 8-isopentenylnaringenin (1), which has been proven to possess estrogen agonist activity in in vitro tests, also produces in vivo estrogenic properties, the effects of 1 on uterus and on bone metabolism were determined in ovariectomized rats. Rats were ovariectomized and treated with 1 at 30 mg/kg/day subcutaneously for two weeks or 17β-estradiol at 0.01 mg/kg/day subcutaneously for two weeks. Ovariectomy resulted in an increase in urinary excretion of bone resorption markers (hydroxyproline, pyridinoline and deoxypyridinoline) and a decrease in bone mineral density of the proximal tibia as well as reduced uterine weight. Treatment with 1 or 17β-estradiol completely suppressed these ovariectomy-induced bone and uterine changes in a qualitatively similar manner. These results demonstrate that 1 acts as an estrogen agonist in the uterus as well as in bone in vivo.

Key words

Prenylflavonoid - isopentenylflavanone - non-steroidal estrogen agonist - phytoestrogen - bone metabolism