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Planta Med 1998; 64(6): 566-570
DOI: 10.1055/s-2006-957516
Papers
Phytochemical Analysis
© Georg Thieme Verlag Stuttgart · New York

Analysis of 6-Hydroxykynurenic Acid in Ginkgo biloba and Ginkgo Preparations

Ines Gräsel, Gerhard Reuter
  • Institute of Pharmacy, Pharmaceutical Biology, Friedrich-Schiller-University Jena, Jena, Germany
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Publication History

1997

1998

Publication Date:
01 February 2007 (online)

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Abstract

Methods for rapid quantitative analysis of 6-hydroxykynurenic acid (6-HKA) by high-performance liquid chromatography (HPLC) and high-performance thin layer chromatography (HPTLC) have been developed. Sample preparation involves solid phase extraction with an ion exchange resin. These methods are used for the determination of the 6-HKA content in various Ginkgo biloba leaf samples, in herbal tea preparations and in a representative number of solid, liquid and homeopathic Ginkgo preparations available in Germany. A simple and effective isolation method for 6-HKA is described.

Key words

Ginkgo biloba - Ginkgoaceae - 6-hydroxykynurenic acid - HPLC - HPTLC - densitometry