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Planta Med 1998; 64(6): 571-572
DOI: 10.1055/s-2006-957517
Letters

© Georg Thieme Verlag Stuttgart · New York

Benzodiazepine Binding Site-Interactive Flavones from Scutellaria baicalensis Roots

Jyh-Fei Liao1 , Hui-Hung Wang1 , Ming-Chih Chen2 , Chien-Chih Chen2 , Chieh-Fu Chen2
  • 1Department and Institute of Pharmacology, National Yang-Ming University, Peitou, Taipei, Taiwan, Republic of China
  • 2National Research Institute of Chinese Medicine, Peitou, Taipei, Taiwan, Republic of China
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1997

1998

Publikationsdatum:
01. Februar 2007 (online)

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Abstract

A benzodiazepine binding assay directed separation led to the identification of 3 flavones baicalein (1), oroxylin A (2), and skullcapflavone II (3) from the water extract of Scutellaria baicalensis root. Compounds 1, 2, and 3 interacted with the benzodiazepine binding site of GABAA receptors with a Ki value of 13.1, 14.6 and 0.36 µmol/L, respectively.