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Planta Med 1998; 64(7): 612-614
DOI: 10.1055/s-2006-957532
Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Hypoglycaemic Activity of an HMG-Containing Flavonoid Glucoside, Chamaemeloside, from Chamaemelum nobile

Gabriele M. König1 , Anthony D. Wright1 , William J. Keller2 , Robert L. Judd3 , Sarah Bates4 , Caroline Day4
  • 1Institute for Pharmaceutical Biology, Technical University of Braunschweig, Braunschweig, Germany
  • 2Department of Pharmaceutical Sciences, McWhorter School of Pharmacy, Samford University, Birmingham, Alabama, U.S.A.
  • 3Division of Molecular Pharmacology, Northeast Louisiana University, Monroe, Louisiana, U.S.A.
  • 4Department of Pharmaceutical and Biological Sciences, Aston University, Birmingham, U.K.
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1997

1998

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

The 3-hydroxy-3-methylglutaric acid (HMG) containing flavonoid glucoside chamaemeloside, has been determined to have in vivo hypoglycaemic activity comparable to that of free HMG. An improved isolation scheme for obtaining chamaemeloside from Chamaemelum nobile is presented.

Key words

3-Hydroxy-3-methylglutaric acid - apigenin - chamaemeloside - Chamaemelum nobile - Asteraceae - Roman chamomile - English chamomile - L6 muscle cells - antidiabetic - diabetes mellitus - hyperglycaemia - hypoglycaemic