Hypoglycaemic Activity of an HMG-Containing Flavonoid Glucoside, Chamaemeloside, from Chamaemelum nobile

Gabriele M. König; Anthony D. Wright; William J. Keller; Robert L. Judd; Sarah Bates; Caroline Day

doi:10.1055/s-2006-957532

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Planta Med 1998; 64(7): 612-614
DOI: 10.1055/s-2006-957532

Paper

Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Hypoglycaemic Activity of an HMG-Containing Flavonoid Glucoside, Chamaemeloside, from Chamaemelum nobile

Gabriele M. König¹ , Anthony D. Wright¹ , William J. Keller² , Robert L. Judd³ , Sarah Bates⁴ , Caroline Day⁴

¹Institute for Pharmaceutical Biology, Technical University of Braunschweig, Braunschweig, Germany
²Department of Pharmaceutical Sciences, McWhorter School of Pharmacy, Samford University, Birmingham, Alabama, U.S.A.
³Division of Molecular Pharmacology, Northeast Louisiana University, Monroe, Louisiana, U.S.A.
⁴Department of Pharmaceutical and Biological Sciences, Aston University, Birmingham, U.K.

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Publication History

1997

1998

Publication Date:
04 January 2007 (online)

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Abstract

The 3-hydroxy-3-methylglutaric acid (HMG) containing flavonoid glucoside chamaemeloside, has been determined to have in vivo hypoglycaemic activity comparable to that of free HMG. An improved isolation scheme for obtaining chamaemeloside from Chamaemelum nobile is presented.

Key words

3-Hydroxy-3-methylglutaric acid - apigenin - chamaemeloside - Chamaemelum nobile - Asteraceae - Roman chamomile - English chamomile - L6 muscle cells - antidiabetic - diabetes mellitus - hyperglycaemia - hypoglycaemic