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Planta Med 1998; 64(7): 628-631
DOI: 10.1055/s-2006-957535
Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Tribulusamide A and B, New Hepatoprotective Lignanamides from the Fruits of Tribulus terrestris: Indications of Cytoprotective Activity in Murine Hepatocyte Culture

Jian-Xin Li1 , Qin Shi2 , Quan-Bo Xiong1 , Jeevan Kumar Prasain1 , Yasuhiro Tezuka1 , Toru Hareyama1 , Zheng-Tao Wang2 , Ken Tanaka3 , Tsuneo Namba1 , Shigetoshi Kadota1
  • 1Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Toyama, Japan
  • 2China Pharmaceutical University, Nanjing, People's Republic of China
  • 3National Research Institute of Police Science, Tokyo, Japan
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Publication History

1997

1998

Publication Date:
04 January 2007 (online)

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Abstract

Tribulusamides A (1) and B (2), new lignanamides embracing two cinnamic amide parts joined in a cis configuration, were isolated from the fruits of Tribulus terrestris, together with four known compounds, N-trans-feruloyltyramine (3), terrestriamide (4), N-trans-coumaroyltyramine (5), and β-sitosterol. The structures were elucidated by 2D-NMR spectroscopy. Addition of compounds 1-5, especially 1 and 2, to primary cultured mouse hepatocytes significantly prevented cell death induced by D-galactosamine (D-GalN)/tumor necrosis factor α (TNF-α).

Key words

Tribulus terrestris - Zygophyllaceae - lignanamide - tribulusamide - D-galactosamine - tumor necrosis factor α (TNF-α) - hepatoprotective activity