Colony Stimulating Factor-Inducing Activity of Isoflavone C-Glucosides from the Bark of Dalbergia monetaria

Kiichiro Kawaguchi; Sérgio de Mello Alves; Takashi Watanabe; Seiichi Kikuchi; Motoyoshi Satake; Yoshio Kumazawa

doi:10.1055/s-2006-957541

Planta Med 1998; 64(7): 653-655
DOI: 10.1055/s-2006-957541

Letter

Colony Stimulating Factor-Inducing Activity of Isoflavone C-Glucosides from the Bark of Dalbergia monetaria

Kiichiro Kawaguchi¹ , Sérgio de Mello Alves² , Takashi Watanabe¹ , Seiichi Kikuchi¹ , Motoyoshi Satake³ , Yoshio Kumazawa⁴

¹Medicinal Plant Garden, School of Pharmaceutical Sciences, Kitasato University, Sagamihara, Kanagawa, Japan
²Empresa Brasileira de Pesquisa Agropecuária - Centro de Pesquisa Agroflorestal da Amazônia oriental, Belém, Pará, Brasil
³Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan
⁴School of Science, Kitasato University, Sagamihara, Kanagawa, Japan

Abstract

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Abstract

To obtain immunomodulating substances from Amazonian medicinal plants, hot water extracts from 21 samples available commercially were tested in terms of mitogenic and colony-stimulating factor (CSF)-inducing activities. Among them, Dalbergia monetaria exhibited the highest CSF-inducing activity. Orobol 8-C-glucoside (OCG-8) and orobol 6-C-glucoside (OCG-6) were isolated from the bark of D. monetaria as major constitutents. The CSF-inducing activity of OCG-8 was higher than that of OCG-6 and a dose-dependent manner at a range of 0.1-l0 mg/mouse. Serum CSF production induced by an intraperitoneal (i.p.) injection with 1 mg OCG-8 reached a peak at 4-6 h later, suggesting that OCG-8 would act on hematopoietic system.

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