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Planta Med 1997; 63(1): 22-26
DOI: 10.1055/s-2006-957596
Papers
Pharmacology and Molecular Biology
© Georg Thieme Verlag Stuttgart · New York

Preventive Effect of Lithospermate B from Salvia miltiorhiza on Experimental Hepatitis Induced by Carbon Tetrachloride or D-Galactosamine/Lipopolysaccharide

Koji Hase, Rena Kasimu, Purusotam Basnet, Shigetoshi Kadota, Tsuneo Namba
  • Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-01, Japan
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Publication History

1996

1996

Publication Date:
04 January 2007 (online)

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Abstract

The water extract from the root of Salvia miltiorhiza Bunge showed a protective effect on cultured rat hepatocytes against carbon tetrachloride (CCl4)-induced necrosis. A further study was carried out to isolate the active constituent. Activity guided fractionation of the extract and chemical analysis gave us lithospermate B (a salt of lithospermic acid B), a tetramer of caffeic acid. Lithospermate B was also found to have a potent hepatoprotective activity in not only in vitro but also in vivo experimental liver injuries induced by CCl4 or D-galactosamine (D-GalN)/lipopolysaccharide (LPS).

Key words

Lithospermate B - Salvia miltiorhiza - Labiatae - hepatoprotective effect - lipopolysaccharide - carbon tetrachloride