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Planta Med 1997; 63(1): 75-79
DOI: 10.1055/s-2006-957609
DOI: 10.1055/s-2006-957609
Papers
Phytochemical Analysis
© Georg Thieme Verlag Stuttgart · New York
Method for the Simultaneous Determination of Aconitum Alkaloids and their Hydrolysis Products by Gas Chromatography-Mass Spectrometry in Human Serum
Weitere Informationen
Publikationsverlauf
1996
1996
Publikationsdatum:
04. Januar 2007 (online)
Abstract
This paper describes a newly developed method using gas chromatography-selected ion monitoring (GC-SIM) for the simultaneous determination of diester-diterpene type Aconitum alkaloids and their hydrolysis products in human serum. When the alkaloids were converted into their TMS derivatives, they produced a well defined peak on selected ion recording (SIR). Good linear response over the range of 100 pg to 7.5 ng was demonstrated for each alkaloid. When the alkaloids were spiked into human serum, good quantitative recovery was observed.
Key words
Ranunculaceae - Aconitum alkaloids - GC-SIM - determination of Aconitum alkaloids - human serum