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Planta Med 1997; 63(1): 81-83
DOI: 10.1055/s-2006-957611
Letters

© Georg Thieme Verlag Stuttgart · New York

Cytotoxicity and Electron Microscopy of Cell Death Induced by Goniothalamin

A. M. Ali1 , M. M. McKeen1 , M. Hamid1 , Q. B. Aun1 , Y. Zauyah2 , H. L. P. Azimahtol3 , K. Kawazu4
  • 1Department of Biotechnology, Faculty of Food Science and Biotechnology, Universiti Pertanian Malaysia, 43400 Serdang, Selangor, Malaysia
  • 2Department of Medical Microbiology and Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia
  • 3Department of Biochemistry, Faculty of Life Sciences, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia
  • 4Department of Bioresources Chemistry, Faculty of Agriculture, Okayama University, Okayama 700, Japan
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Publikationsverlauf

1996

1996

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultra-structural level, goniothalamin-induced cytotoxicity revealed a necrotic mode of cell death towards MCF-7 cells.