Dual Inhibitory Activities of Tannins from Hamamelis virginiana and Related Polyphenols on 5-Lipoxygenase and Lyso-PAF: Acetyl-CoA Acetyltransferase1

Claudia Hartisch; Herbert Kolodziej; Fritz von Bruchhausen

doi:10.1055/s-2006-957623

Planta Medica, Table of Contents

Planta Med 1997; 63(2): 106-110
DOI: 10.1055/s-2006-957623

Papers

Pharmacology and Molecular Biology
© Georg Thieme Verlag Stuttgart · New York

Dual Inhibitory Activities of Tannins from Hamamelis virginiana and Related Polyphenols on 5-Lipoxygenase and Lyso-PAF: Acetyl-CoA Acetyltransferase¹

Claudia Hartisch² , Herbert Kolodziej² , Fritz von Bruchhausen³

²Institut für Pharmazie II, Pharmazeutische Biologie, Freie Universität Berlin, Berlin, Germany
³Institut für Pharmakologie, Universitätsklinikum Rudolf Virchow, Berlin, Germany

1 Presented in parts during the meeting of the Society of Medicinal Plant Research, Halle/Saale, Germany, Sept. 1995. Part of the projected thesis of C Hartisch

Abstract

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Abstract

In the present study, the effects of tannins obtained from various plant sources on the activity of 5-LOX and AT were examined. With IC₅₀ values ranging from 1.0 to 18.7 µM, hamamelitannin and the galloylated proanthocyanidins isolated from Hamamelis virginiana L. were found to be most potent inhibitors of 5-LOX. Unlike the 5-LOX study, hamamelitannin proved to be ineffective in the AT assay. Potent candidates are represented by the group of B-type proanthocyanidins. Structure-activity relationships regarding the in vitro inhibitory potency of the polyphenols in the biological assays are discussed.

key words

Hamamelis virginiana - Hamamelidaceae - hamamelitannin - proanthocyanidins - 5-lipoxygenase - lyso-PAF: acetyl-CoA acetyltransferase

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