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DOI: 10.1055/s-2006-957624
© Georg Thieme Verlag Stuttgart · New York
Inhibition of 5α-Reductase and Aromatase by the Ellagitannins Oenothein A and Oenothein B from Epilobium Species
Publikationsverlauf
1996
1996
Publikationsdatum:
04. Januar 2007 (online)
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Abstract
Species of the genus Epilobium (Onagraceae) have been investigated for their activity against 5α-reductase and aromatase, two enzymes which are involved in the aetiology of benign prostatic hyperplasia (BPH). Activity-guided fractionation has led to the identification of two macrocyclic ellagitannins, oenothein A (1) and oenothein B (2), as the main constituents responsible for the inhibition of the two enzymes. Quantitation of oenothein B in 10 different species of Epilobium has shown that amounts of up to 14% in the crude plant extracts are possible.
key words
Epilobium - Onagraceae - ellagitannins - aromatase inhibition - 5α-reductase inhibition - prostate - benign prostatic hyperplasia