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DOI: 10.1055/s-2006-957628
© Georg Thieme Verlag Stuttgart · New York
Endothelium-Dependent Higenamine-Induced Aortic Relaxation in Isolated Rat Aorta
Publication History
1996
1996
Publication Date:
04 January 2007 (online)
Abstract
The pharmacological action of higenamine in isolated rat aorta was investigated. Although the beta-adrenoceptor antagonist propranolol (1 × 10-5M) completely blocked the beta-adrenoceptor agonist higenamine in inducing a positive chronotropic activity in isolated mouse atria, the higenamine-induced aortic relaxation was not completely antagonized by this concentration of propranolol. The present data also demonstrate that the higenamine-induced aortic relaxation was attenauted in the absence of endothelium. These findings suggest that the beta-adrenoceptor specificity to higenamine in aorta is different from that of beta-1 in atria; moreover, the beta-adrenoceptors sensitive to higenamine are mainly located in the endothelial layer.
key words
Aconitum japonicum - Ranunculaceae - benzyl-isoquinoline alkaloid - higenamine - aortic relaxation - beta-adrenoceptor - endothelium - propranolol