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Planta Med 1997; 63(2): 158-160
DOI: 10.1055/s-2006-957635
Papers
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Konishiol, A New Sesquiterpene, and Bioactive Components from Cunninghamia konishii

Kan He, Guoen Shi, Lu Zeng, Qing Ye, Jerry L. McLaughlin
  • Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, U.S.A
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Publication History

1996

1996

Publication Date:
04 January 2007 (online)

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Abstract

Three sesquiterpenes, konishiol (1), cadalenol (2), 3-cedranol (3), one diterpene, manool (4), and one lignan, (+)-tsugacetal (5), have been isolated, for the first time, from the whole plant of Cunninghamia konishii by using bioactivity-directed fractionation. Compound 1 is new to the literature, and its chemical structure was determined by various spectroscopic analyses including EIMS, HREIMS, NOE, NOESY, and by preparing its di-acetyl derivative (la). Compounds 2-5 showed moderate to weak bioactivities in brine shrimp (BST) and mosquito larvae (YFM) bioassays as well as cytotoxicities against three human solid tumor cell lines.

key words

Cunninghamia konishii - Pinaceae - sesquiterpenes - konishiol - cytotoxic activity