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Planta Med 1997; 63(2): 183-186
DOI: 10.1055/s-2006-957642
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© Georg Thieme Verlag Stuttgart · New York

Cycloartane Triterpene Glycosides from the Roots of Astragalus melanophrurius

ihsan Çaliş1 , Ayşen Yürüker1 , Deniz Taşdemir2 , Anthony D. Wright2 , 4 , Otto Sticher2 , Ying-De Luo3 , John M. Pezzuto3
  • 1Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, TR-06100 Ankara, Turkey
  • 2Department of Pharmacy, Swiss Federal Institute of Technology ETH Zurich, CH-8057 Zürich, Switzerland
  • 3Program for Collaborative Research, College of Pharmacy, University of Illinois at Chicago, Chicago, U.S.A.
  • 4Department of Pharmaceutical Biology, Technical University of Braunschweig, D-38106 Braunschweig, Germany
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Publication History

1996

1996

Publication Date:
04 January 2007 (online)

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Abstract

From the roots of Astragalus melanophrurius eight known saponins (1-8) were isolated. Based on spectral data (IR, 1H- and 13C-NMR, and FABMS), the structures were established as astrasieversianins II (1) and X (4), astragalosides I (2), II (3), IV (5) and VI (7), and cyclocanthosides E (6) and G (8). The isolates were evaluated in a broad range of bioassay systems and found to be inactive. Modest antibacterial activity was observed, however, as was immunomodulatory activity, as indicated by stimulation of isolated human lymphocytes.