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Planta Med 1997; 63(3): 196-198
DOI: 10.1055/s-2006-957651
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Pharmacology and Molecular Biology
© Georg Thieme Verlag Stuttgart · New York

Antimicrobial Activity of Some 13-Alkyl Substituted Protoberberinium Salts

Kinuko Iwasa, Miyoko Kamigauchi, Makiko Sugiura, Hiroaki Nanba
  • Kobe Pharmaceutical University, 4-19-1, Motoyamakita, Higashinada, Kobe 658, Japan
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Publication History

1996

1996

Publication Date:
04 January 2007 (online)

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Abstract

Several 13-alkyl substituted analogs of berberine and palmatine were found to be highly active against two types of Staphylococcus aureus (S1 and S2) of different origin. The most active 13-hexylberberine was 8 times more active (against S1) and the same order active (against S2) as kanamycin sulfate. 13-Hexylpalmatine displayed an activity against S. aureus (S1) 4 times greater than that of kanamycin sulfate. The activities of 13-hexylberberine against two types of S. aureus were 64 and 128 times greater than those of the clinically used alkaloid berberine. Additionally two hexyl derivatives possessed antifungal activity.

key words

13-Alkylprotoberinium salts - antimicrobial activity - antifungal activity