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DOI: 10.1055/s-2006-957670
© Georg Thieme Verlag Stuttgart · New York
Inhibition of Phospholipase Cγ1 by the Prenylated Flavonoids from Sophora flavescens
Publication History
1996
1996
Publication Date:
04 January 2007 (online)
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Abstract
The effect on the phospholipase Cγ1 activity of eleven prenylated flavonoids from Sophora flavescens was investigated. These flavonoids exhibited relatively strong inhibitory activity with IC50 values ranged from 7.5 × 10-6M to 35 × 10-6M with the exception of kushenol H (4) (IC50value; > 5.3 × 10-4M). The presence of C3-OH resulted in a significant diminution of activity and the configuration of C3-OH is likely to be another factor influencing the activity. In addition, hydration of the C-4′″-C-5′″ double bond of the lavandulyl side chain caused complete loss of activity. These data suggest that the presence and configuration of C3-OH are related to the inhibitory activity and the lavanduiyl side chain is also important for high inhibitory activity against PLCγ1.