Antidiabetic Effect of Seishin-kanro-to in KK-Ay Mice

Toshihiro Miura; Mami Kako; Eriko Ishihara; Masaru Usami; Hideki Yano; Keiichiro Tanigawa; Kazuhiko Sudo; Yutaka Seino

doi:10.1055/s-2006-957691

Planta Medica, Table of Contents

Planta Med 1997; 63(4): 320-322
DOI: 10.1055/s-2006-957691

Papers

Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Antidiabetic Effect of Seishin-kanro-to in KK-Ay Mice

Toshihiro Miura¹ , Mami Kako¹ , Eriko Ishihara¹ , Masaru Usami¹ , Hideki Yano¹ , Keiichiro Tanigawa¹ , Kazuhiko Sudo³ , Yutaka Seino²

¹Suzuka University of Medical Science and Technology, 1001-1 Kishioka, Suzuka, Mie 510-02, Japan
²Department of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606, Japan
³Tsumura Co., 2 Rokubancho Chiyoda-ku Tokyo 102, Japan

Abstract

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Abstract

The hypoglycemic effect of Seishin-kanro-to (SK) was investigated in KK-Ay mice, one of the non-insulin dependent diabetic mellitus types. SK (1700 mg/kg) reduced the blood glucose of KK-Ay mice from 557 ± 17 to 383 ± 36 mg/100 ml 7 hours after single oral administration (P < 0.001). SK also decreased the blood glucose and improved glucose tolerance 5 weeks after repeated administration in KK-Ay mice. These results support, therefore, the use of SK in patients with diabetes and confirm its role as a traditional medicine. In addition, the active plants of SK were identified as the rhizome of Anemarrhena asphodeloides Bunge and the radix of Rehmannia glutinosa Liboschitz.

Key words

Antidiabetic effect - Seishin-kanro-to - oriental traditional medicine - KK-Ay mice - oral glucose tolerance - Anemarrhena asphodeloides - Liliaceae - Rehmannia glutinosa - Scrophulariaceae

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