Download PDF
Planta Med 1997; 63(4): 360-361
DOI: 10.1055/s-2006-957701
Letters

© Georg Thieme Verlag Stuttgart · New York

Decursinol Angelate: A Cytotoxic and Protein Kinase C Activating Agent from the Root of Angelica gigas

Kyung-Seop Ahn1 , 2 , Woong-Seop Sim2 , In-Kuk Lee1 , Young-Bae Seu4 , Ik-Hwan Kim3
  • 1Korea Research Institute of Bioscience and Biotechnology, KIST, P.O. Box 115, Yusong, Taejon 305-600, Republic of Korea
  • 2Department of Biology, Korea University, Seoul 136-701, Republic of Korea
  • 3Graduate School of Biotechnology, Korea University, Seoul 136-701, Republic of Korea
  • 4Department of Microbiology, Kyungpook National University, Taegu 702-701, Republic of Korea
Further Information

Publication History

1996

1996

Publication Date:
04 January 2007 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

A cytotoxic compound was purified from the root of Angelica gigas Nakai by normal phase HPLC. As a result of the structure analysis by mass, IR, 1H-NMR, and 13C-NMR spectrometry, the compound was identified as decursinol angelate, a structural isomer of decursin, and characterized originally from Sesei grandivittatum. Decursinol angelate showed in vitro cytotoxicity and protein kinase C activating activities like decursin.