Bisbenzylisoquinoline Alkaloids from Stephania cepharantha and their Effects on Proliferation of Cultured Cells from the Murine Hair Apparatus

Koichi Nakaoji; Hidekazu Nayeshiro; Takao Tanahashi; Yuko Su; Naotaka Nagakura

doi:10.1055/s-2006-957726

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Planta Med 1997; 63(5): 425-428
DOI: 10.1055/s-2006-957726

Papers

Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Bisbenzylisoquinoline Alkaloids from Stephania cepharantha and their Effects on Proliferation of Cultured Cells from the Murine Hair Apparatus

Koichi Nakaoji¹ , Hidekazu Nayeshiro¹ , Takao Tanahashi² , Yuko Su² , Naotaka Nagakura²

¹Sunstar Inc., Takatsuki, Osaka, 569-11, Japan
²Kobe Pharmaceutical University, Higashinada-ku, Kobe, 658, Japan

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Publication History

1996

1997

Publication Date:
04 January 2007 (online)

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Abstract

Bisbenzylisoquinoline alkaloids were isolated from Stephania cepharantha Hayata and their proliferative activities on cultured hair cells from the murine skin were evaluated. Cepharanthine (1), cepharanoline (9), isotetrandrine (2), and berbamine (7) showed significant activities in the range of 0.01-0.1 µg/ml, but had no activity on cultured keratinocytes or fibroblasts from the murine skin.

key words

Hair cells - proliferation - Stephania cepharantha - Menispermaceae - bisbenzylisoquinoline alkaloids - cepharanthine