6-Methoxy-N-methyl-1,2,3,4-tetrahydro-β-carboline from Evodiae Fructus

Li-Li Yu; Li-Kang Ho; Jyh-Fei Liao; Chieh-Fu Chen

doi:10.1055/s-2006-957739

Planta Medica, Inhaltsverzeichnis

Planta Med 1997; 63(5): 471-472
DOI: 10.1055/s-2006-957739

Letters

6-Methoxy-N-methyl-1,2,3,4-tetrahydro-β-carboline from Evodiae Fructus

Li-Li Yu¹ , Li-Kang Ho¹ , Jyh-Fei Liao¹ , Chieh-Fu Chen²

¹Department and Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan
²National Research Institute of Chinese Medicine, Taipei, Taiwan

Abstract

als PDF herunterladen

Abstract

A receptor binding assay directed separation has led to the identification of a minor alkaloid 6-methoxy-N-methyl-1,2, 3,4-tetrahydro-β-carboline (1) from the Chinese herbal drug Evodiae Fructus [EF, the dried, unripe fruit of Evodia rutaecarpa Look. f. et Thomas (Rutaceae)]. The structure of compound 1 was elucidated by means of spectroscopic methods and a comparison with synthetic materials. Compound 1 interacted with 5-HT_1A and 5-HT₂ receptors with a moderate K_i value of 78 and 1.2 µM, respectively. Compound 1 is found in EF and the genus Evodiae for the first time.

PDF (183 kb)