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Planta Med 1997; 63(6): 540-543
DOI: 10.1055/s-2006-957759
Papers
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Retrodihydrochalcones and Homoisoflavones Isolated from Thai Medicinal Plant Dracaena loureiri and their Estrogen Agonist Activity

Kazuo Ichikawa1 , Masahiro Kitaoka1 , Motohiko Taki2 , Sachiko Takaishi2 , Yasuteru lijima2 , Malee Boriboon3 , Toshiyuki Akiyama1
  • 1Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., 2-58 Hiromachi 1-Chome, Shinagawa-ku, Tokyo 140, Japan
  • 2Pharmacology and Molecular Biology Research Laboratories, Sankyo Co., Ltd., 2-58 Hiromachi 1-Chome, Shinagawa-ku, Tokyo 140, Japan
  • 3Thai-Sankyo Co., Ltd. 607 Asoke-Dindaeng Road, Bangkok 10400, Thailand
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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

Biological evaluation of the extract prepared from the stem wood of Dracaena loureiri, a Thai folkloric medicine called “Chan-daeng”, revealed a significant capacity to inhibit [3 H]-estradiol binding to the estrogen receptor. During the course of separation, two novel (1 and 2) and two known retrodihydrochalcones (3 and 4), in addition to three known homoisoflavones (5,6, and 7), were isolated. The structures of compounds 1 and 2 were established by NMR and MS studies by correlating their spectroscopic properties with those of 3 and 4. Each isolate was assessed for its estrogenic activity. Compounds 1 and 6 exhibited activity comparable to that of genistein and daidzein.

Key words

Dracaena loureiri Gagnep - Agavaceae - retrodihydrochalcone - homoisoflavone - traditional medicine - estrogen agonist - phytoestrogen