Planta Med 1997; 63(6): 552-553
DOI: 10.1055/s-2006-957763
Letters

© Georg Thieme Verlag Stuttgart · New York

Polyacetylene Analogs, Isolated from Hairy Roots of Panax ginseng, Inhibit Acyl-CoA : Cholesterol Acyltransferase

Byoung-Mog Kwon1 , Sook-Hee Ro2 , Mi-Kyoung Kim1 , Ji-Youn Nam1 , Hyun-Ju Jung1 , Ihn-Rhan Lee2 , Young-Kook Kim1 , Song-Hae Bok1
  • 1Protein Regulator RU, Korea Research Institute of Bioscience & Biotechnology, KIST, P.O. Box 115, Yoosung, Taejon, Korea 305-600
  • 2Ewha Womans University, College of Pharmacy, Seoul, Korea
Further Information

Publication History

1997

1997

Publication Date:
04 January 2007 (online)

Abstract

In the course of our screening program for acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from Korean herbal medicines, ACAT inhibitors were isolated from the hairy roots of Panax ginseng (Araliaceae) and identified as panaxynol, panaxydol, panaxydiol, and panaxytriol. These active compounds inhibit rat liver ACAT with IC50 values of 94, 80, 45 and 79 µM, respectively.